NOVEL CONCEPTS IN SUPPORT OF CLINICAL MANAGEMENT OF AMR
A miniaturized isothermal nanocalorimetric platform for fast and accurate heat flow measurements
ESR13 will develop a miniaturized isothermal platform for nanocalorimetric measurements on bacteria evaluating their metabolic activity via the produced heat flow. The system will be interfaced with a microfluidic chip to dynamically apply reagents, nutrients, or drugs. Inhibitory effects of antimicrobial compounds will be evaluated aiming to distinguish drug-resistant strains from drug-susceptible ones. The sensitivity of the approach is expected to permit to diagnose presence of bacteria well before optical detection is possible.
Specific profile requirements
- Study profile in microengineering or microsystems
- Affinity for biochemistry and biology
- Experience with a multidisciplinary project.
We offer a multi-disciplinary research project in the field of Microelectromechanical Systems technology and Bio-engineering. Excellent infrastructure at EPFL (central clean room facilities for micro and nanotechnology, materials characterization, engineering, etc). International, multi-disciplinary research community.
Send electronic applications to: Prof. Martin Gijs, Ecole Polytechnique Fédérale de Lausanne, Laboratory of Microsystems, Station 17, 1015 Lausanne, Switzerland, web: http://lmis2.epfl.ch e-mail: Martin.Gijs@epfl.ch