ESR3 small

Novel concepts in support of improving clinical management of RTIs: Distinguishing viral from bacterial pneumonia

A digital Elisa platform

For community acquired respiratory tract infections (RTI), the greatest clinical need is for the physician to be able to rapidly distinguish patients presenting with viral RTI from those with bacterial RTI. However, viruses not always have dsDNA, making the development of a nucleic acid based assay challenging. Proteins provide excellent alternative targets, attainable by antibody-based tests. Those tests do not require target amplification, making them inherently fast. In this project, the candidate will build on existing technology to develop a multiplexed digital ELISA for the detection of specific RTI pathogens which will be subsequently integrated on a OSTE-based low-cost disposable microfluidic chip.

  • Arenberg Doctoral School, KU Leuven University (Belgium).
    MeBioS-Biosensor group (www.biosensors.be)
    Willem de Croylaan 42, Heverlee (Leuven)
    Belgium
  • Kungliga Tekniska Högskolan (KTH) – Micro and nanosystems (MST) department – OSQULDAS VÄG 10, Stockholm – Sweden
  • Consejo Superior de Investigaciones Scientificas (CSIC)
    Institut de Microelectrònica de Barcelona
    08193 Cerdanyola del Vallès, Bellaterra
    Spain

Specific profile requirements

  • You have a Master degree cum laude (> 70%) in Bioscience Engineering, Biomedical Sciences, Biosciences or equivalent
  • Previous experience in development of antibody-based bioassays, ELISA work and/or microfabrication technologies will be considered as a strong asset
  • You are highly motivated to do research in a dynamic environment and as part of this unique EU training program
  • You are communicative, creative, eager to learn and able to work independently as well as part of the team
  • Candidates must be available for starting between April 1 and September 1, 2016