ESR4 small

Novel concepts in support of improving clinical management of RTIs: Distinguishing viral from bacterial pneumonia

A molecular lateral flow assay

For community acquired respiratory tract infections (RTI), the greatest clinical need is for the physician to be able to rapidly distinguish patients presenting with viral RTI from those with bacterial RTI. Viruses not always have dsDNA, making the development of a nucleic acid based assay challenging. Loop-mediated isothermal amplification (LAMP) can be modified to enable handling both DNA and RNA while its properties (isothermal, good specificity,…) make it an ideal technology for POC diagnostics. In this project, the candidate will develop singleplex and multiplex LAMP assays. The resulting bioassay will be implemented on a lateral flow device with sensitive readout.

  • Arenberg Doctoral School, KU Leuven University (Belgium).
    MeBioS-Biosensor group (
    Willem de Croylaan 42, Heverlee (Leuven)
  • Kungliga Tekniska Högskolan (KTH) – Micro and nanosystems (MST) department – OSQULDAS VÄG 10, Stockholm – Sweden
  • NXP Semiconductors High Tech Campus 60, 5656 AG Eindhoven
    The Netherlands

Specific profile requirements

  • You have a Master degree cum laude (> 70%) in Bioscience Engineering, Biomedical Sciences, Biosciences or equivalent
  • Previous experience in DNA/RNA work and development of molecular bioassays will be considered as a strong asset
  • You are highly motivated to do research in dynamic environment and as part of this unique EU training program
  • You are communicative, creative, eager to learn and able to work independently as well as part of the team
  • Candidates must be available for starting between April 1 and September 1, 2016