POC Molecular IVDs generating actionable information in support of improving clinical management of UTIs

A clinically derived multiplex molecular bioassay

The clinical usefulness of any diagnostic test largely depends on the bioassay. This project aims to produce an optimal bioassay for urinary tract infections (UTI) through outreach to the end-users and assessment of the actual clinical need per setting (primary care, hospital care,…). This end-user perspective will be complemented by the actual quantification of microorganisms in urine by culture-based methods, metagenomic analysis and flow cytometry, all of which will be correlated to clinical symptoms. Important strains, such as E. coli, will be sequenced, typed and differentiated in relation to clinical outcome, infective dose and sequence specific markers of infection. Building on this information, the actual bioassay will be developed and implemented on a POC platform (link to other project).

Specific profile requirements

• Strong molecular biology and microbiology background (bio-engineer, biochemist,…)
• Interest in technical aspects (microfluidics, filtration, mixing,…)
• Creative and capable of thinking out-of-the box
• Capable of working independently (planning and executing experiments)
• Excellent interpersonal skills, team player