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KEY INNOVATIONS ENABLING POC MANAGEMENT OF BSI

Fully automated, microfluidic, low cost sample preparation module to isolate intact bacteria or bacterial DNA from whole blood

One of the main challenges for the diagnosis of BSI is the recovery and subsequent detection of very small amounts of organisms from a large amount of blood. ESR 8 will develop a selective cell lysis strategy, allowing complete lysis of all blood cells in 10 ml of whole blood, yielding viable bacteria for downstream processing. The candidate will also develop Isothophoresis (ITP) driven migration of whole bacteria to a designated location for analysis. ITP focuses analytes such as bacterial cells or DNA in between slightly slower and faster moving electrolytes, allowing their manipulation in very small volumes, the latter being highly beneficial for downstream processing. ESR 8 will collaborate with ESR9 who will develop sensitive RCA of large numbers of targets followed by on-chip detection of amplified nucleic acid.

  • Kungliga Tekniska Högskolan (KTH)
    Clinical microfluidics lab (www.scilifelab.se)
    OSQULDAS VÄG 10, Stockholm
    Sweden
  • Technion, Israel Institute of Technology Microfluidics Technologies, Mechanical Engineering Faculty Technion City, Haifa 3200003, Israel
  • University of Antwerp – Vaccine & Infectious Disease Institute
    Campus Drie Eiken – Universiteitsplein 1
    2610 Antwerpen
    Belgium

Specific profile requirements

  • You have a master degree with distinction in biomedical sciences or bioscience engineering. Candidates with a degree in Electrical/Physical/mechanical engineering with an interest or experience in applying this knowledge to (micro)biological/medical tools are equally welcome to apply.
  • Experience with microfluidics and molecular biology are an asset
  • Must be able to start on Aug 1, 2016.