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KEY INNOVATIONS ENABLING POC MANAGEMENT OF BSI

An isotachophoretically driven rolling circle DNA amplification module and sensitive nanowire readout based on rolling circle product stretching and metal deposition

The potential amount of targets for many diseases can be very high. The project comprises the development of an isotachophoretically driven rolling circle DNA amplification module. The molecular assay will be combined with a sensitive nanowire readout based on rolling circle product stretching and subsequent metal deposition. This concept constitutes a sophisticated and massively multiplexed (several hundreds of targets), yet simple and rapid molecular test for infectious diagnostics.

  • Molecular Diagnostics, Department of biochemistry and biophysics, Stockholm University and Science for Life Laboratories, Se-171 21 Solna, Sweden
  • Microsystem Technology, School of Electrical Engineering, KTH – Royal Institute of Technology, Osquldas väg 10114 28, Stockholm, Sweden
  • Microfluidics Technologies, Mechanical Engineering Faculty – Technion, Israel Institute of Technology, Technion City, Haifa 3200003, Israel

Specific profile requirements

  • Molecular biologist with technical skills or bioengineer
  • Desired knowledge: molecular biology, biochemistry, electrochemistry, microfluidics, surface chemistry, nanotechnology
  • Practically oriented problem solving person desired