Ismail Tugberk Kaya - ESR11
NOVEL CONCEPTS IN SUPPORT OF CLINICAL MANAGEMENT OF AMR
A digital microfluidic platform capable of detecting carbapenem resistance directly from a clinical sample
Carbapenem resistance is on the rise and a significant threat to proper antibiotic treatment. Due to the massive amount of genes and variants involved, such resistance is difficult to adequately capture using molecular diagnostics. Various phenotypic approaches, such as MALDI-TOF and CARBA NP, have been developed. However, these start from a pure culture, which in itself requires a day of prior growth, delaying targeted administration of antibiotics. In this project, the Carba NP test will be adapted for use directly on clinical samples, requiring investigations in bacterial extraction and seeding as well as the comparison of various ultrasensitive detection approaches.
Point of care systems for applications in resource limited settings. Rapid and inexpensive diagnostic tools for global health problems. Interdisciplinary research combining the clinical relevance with recent technological advancements.
- Bogazici University, Turkey
MSc in Molecular Biology and Genetics, 2016
- Kungliga Tekniska Högskolan (KTH)
Micro and nanosystems (MST) department
Osquldas väg 10, Stockholm
Innovation Unit-Biology Research Department
38390 La Balme Les Grottes