Saba Safdar - ESR3

Novel concepts in support of improving clinical management of RTIs: Distinguishing viral from bacterial pneumonia

A digital Elisa platform

For community acquired respiratory tract infections (RTI), the greatest clinical need is for the physician to be able to rapidly distinguish patients presenting with viral RTI from those with bacterial RTI. However, viruses not always have dsDNA, making the development of a nucleic acid based assay challenging. Proteins provide excellent alternative targets, attainable by antibody-based tests. Those tests do not require target amplification, making them inherently fast. In this project, the candidate will build on existing technology to develop a multiplexed digital ELISA for the detection of specific RTI pathogens which will be subsequently integrated on a OSTE-based low-cost disposable microfluidic chip.

 

 

 

 

 

 

I am interested in all things translational; pushing technology and solutions off the lab bench and into the market to benefit those in need. My training in biology and biomedical engineering puts me in a unique position to leverage both for innovative solutions. I am particularly intrigued by the potential of microfluidic technologies, and am inclined towards exploiting them for point-of-care diagnostics and lab-on-a-chip solutions.

 

 

 

 

National University of Sciences & Technology, Pakistan/Arizona State University
MSc Biomedical Engineering 2016

 

 

 

 

  • Kungliga Tekniska Högskolan (KTH)
    Micro and Nanosystems (MST) Department
    OSQULDAS VÄG 10
    Stockholm, Sweden

  • Consejo Superior de Investigaciones Scientificas (CSIC)
    Institut de Microelectrònica de Barcelona
    08193 Cerdanyola del Vallès, Bellaterra
    Spain

Publications

  • Selection of Reference Genes in Wheat against Titanium Dioxide and Zinc Oxide. Nanotoxicity. S. Safdar, N. Virk, X. Cheng, S. Tufail, H. A. Janjua, M. F. Bhatti, A. G. Kazi. Conference Proceedings NanoSMAT USA (2014)
  • Bacteriophage Applications & Phage therapy: A systemic review. W. N. Choudhry, I. U. Haq, S. Safdar, I. Qadri. NUST Journal of Natural Sciences, Vol 1 No. 1, ISSN 2072-4659 (2010)

Looking for interesting collaborations?