Sharath Iyengar - ESR8
KEY INNOVATIONS ENABLING POC MANAGEMENT OF BSI
Fully automated, microfluidic, low cost sample preparation module to isolate intact bacteria or bacterial DNA from whole blood
One of the main challenges for the diagnosis of BSI is the recovery and subsequent detection of very small amounts of organisms from a large amount of blood. ESR 8 will develop a selective cell lysis strategy, allowing complete lysis of all blood cells in 10 ml of whole blood, yielding viable bacteria for downstream processing. The candidate will also develop Isothophoresis (ITP) driven migration of whole bacteria to a designated location for analysis. ITP focuses analytes such as bacterial cells or DNA in between slightly slower and faster moving electrolytes, allowing their manipulation in very small volumes, the latter being highly beneficial for downstream processing. ESR 8 will collaborate with ESR9 who will develop sensitive RCA of large numbers of targets followed by on-chip detection of amplified nucleic acid.
My interests are related to Biosensors. Integrating nanotechnology with Biophysical aspects to build a biosensor excites me. This basically means that I’m passionate about Biology, Physics (Quantum physics and Astrophysics included) and Nanotechnology. In addition, if I get a chance to study, I would love to work on Volcanology , Paleontology and Lightening Engineering.
Technical University Dresden, Germany
MSc Nanobiophysics 2016
Israel Institute of Technology Microfluidics Technologies
Mechanical Engineering Faculty Technion City
Haifa 3200003, Israel
- University of Antwerp – Vaccine & Infectious Disease Institute
Campus Drie Eiken – Universiteitsplein 1